3D Printing Advances Stem Cell Research

An episode of the Syfy series Eureka revolved around the idea of using 3D printers to create full-scale human clones. Of course, the plot also involved the clones being used to replace people with evil clones in a trope made popular by the old movie Invasion of the Body Snatchers. As of yet, no 3D printer is capable of that level of biofabrication, much less than instilling a specific moral compass, but scientists are making strides toward using the technology to build smaller parts of the human body.

Collaboration between researchers at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, US, has resulted in an improved method for building embryonic stem cells from scratch. Rather than manufacturing the cells in a Petri dish by encouraging growth, researchers have been able to print cells directly using additive manufacturing (AM). This development has the potential not only to improve stem cell research, but could also result in building more complex organic structures.

The standard method for building cells is to grow them in a Petri dish, or to slowly drip them into place, eventually aggregating the cell in a manner similar to how you might dribble wet sand to build a sand castle. Both of those method result in fairly unsophisticated structures without the homogeneity of cells that develop naturally.

By using AM, scientists are able to build specific chains of cells in three dimensions. Additionally, by printing the cells using hydrogel, the structures are given a measure of support. Generally, cells are so fragile that they can “break” if not treated delicately. Hydrogel acts as a sort of scaffolding, and also allows for a variety of cells to be built in close proximity, perhaps leading to the creation of micro-organs.

“It was really exciting to see that we could grow embryoid body in such a controlled manner,” said Wei Sun, a lead author on the paper. “The grown embryoid body is uniform and homogenous, and serves as a much better starting point for further tissue growth.”

The research findings were printed in the journal Biofabrication, under the title “Three-dimensional bioprinting of embryonic stem cells directs highly uniform embryoid body formation.” Below you’ll find a video that discusses the potential offered by stem cell research.

Source: LiveScience